Association of hsCRP and Serum Kalirin Levels with the Development and Severity of Premature Coronary Artery Disease in Iraqi Patients

Mustafa Kazum Mahmood; Eman Saadi Saleh; Ghassan Mohammed Mahmood

doi:10.54133/ajms.v7i1.1272

Authors

Mustafa Kazum Mahmood College of Pharmacy, University of Uruk, Baghdad, Iraq
Eman Saadi Saleh Department of Clinical Laboratory Sciences, College of Pharmacy, University of Baghdad, Baghdad, Iraq
Ghassan Mohammed Mahmood Baghdad Center for Catheterization, Medical City, Baghdad, Iraq https://orcid.org/0009-0001-8197-1903

DOI:

https://doi.org/10.54133/ajms.v7i1.1272

Keywords:

Coronary artery disease, hsCRP, Kalirin, Premature coronary artery disease

Abstract

Background: Coronary artery disease (CAD) is a major contributor to morbidity and mortality worldwide. Early-onset CAD, also known as PCAD, is a severe form of CAD associated with high mortality and a poor prognosis. Early diagnosis is crucial to reducing complications. While hsCRP is an established biomarker for CAD, kalirin is a potential novel biomarker due to its role in promoting smooth muscle proliferation and endothelial dysfunction. Objective: To evaluate the relationship between serum kalirin and hsCRP levels with the presence and severity of PCAD and to compare the diagnostic value of both biomarkers. Method: The study recruited 92 participants into two groups: the PCAD group (46) included patients with confirmed CAD by angiographic findings and the second group was the non-CAD group (46) with negative findings by coronary angiography. The levels of serum kalirin and hsCRP were measured for both groups using enzyme-linked immunosorbent assay (ELISA) kits. Results: Serum levels of kalirin and hsCRP were strongly associated with the presence of PCAD (p<0.001), and both biomarkers were associated with disease severity (p=0.002, <0.001, respectively). ROC analysis showed that hsCRP possesses a slight advantage (AUC=0.796) over kalirin (ROC=0.717) as a diagnostic marker for PCAD. Conclusions: Serum kalirin and hsCRP levels are associated with PCAD and with the severity of the disease, both markers possess moderate diagnostic capabilities for PCAD with a slight advantage for hsCRP.

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