The Effect of Hypertension and Beta-Blocker Antihypertensive Drug on Bone Mineral Density Value At the Mandibular Cortex in Mental and Gonial Regions in Hounsfield Unite Using Computed Tomographic Study

Abstract

Computed tomography is a medical technique that measures bone mineral density. Both hypertension and Beta-Blocker antihypertensive drug are associated with abnormality in calcium metabolism .The aim of this study was to study the effect of hypertension and Beta Blocker antihypertensive drug on bone mineral density in Hounsfield unite using computed tomography. Material and Method: This prospective study was conducted on computed tomographic image of 150 men aged between (35- 85) years. Data were grouped into three categories according to their blood pressure: normotensive group (n=50), Hypertensive treated for > 8 months group (n=50) and Untreated hypertensive/recently diagnosed group (n=50).. Bone mineral densities were measured in each sample in both mental and gonial areas in Hounsfield unite.Results: There were a statically significant difference in bone mineral density in both mental and gonial area among the three study groups. Bone mineral density was highest in group 2 and lowest in group 3. P value was < 0.001 among the three study groups. There was a positive linear correlation between bone mineral density and the duration of antihypertensive drug used and there was a negative linear correlation between bone mineral density and duration of hypertension diseaseConclusion: Computed tomography is a good diagnostic method to measure the value of bone mineral density in hypertensive patients. Bone mineral density is highly affected by increasing blood pressure and by antihypertensive treatment and affected by duration of the disease and the treatment.