Preparation and Evaluation of in situ Ophthalmic Gel with a Dual Triggered Mechanism for the Delivery of Gatifloxacin and Betamethasone

Fatima Mustafa Ali; Athmar Dhahir Al-Shohani

doi:10.54133/ajms.v6i2.597

المؤلفون

Fatima Mustafa Ali Department of Pharmaceutics, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq https://orcid.org/0009-0009-2913-4591
Athmar Dhahir Al-Shohani Department of Pharmaceutics, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq

DOI:

https://doi.org/10.54133/ajms.v6i2.597

الكلمات المفتاحية:

Betamethasone، Drug delivery، Gatifloxacin، Gellan gum، In situ ophthalmic gel، Poloxamer

الملخص

تتمثل التحديات الرئيسية التي يواجهها علماء الصياغة في التوصيل البصري في الإزالة السريعة قبل القرنية والتطبيق المتعدد، خاصة مع الأدوية المضادة للميكروبات. تهدف هذه الدراسة إلى تطوير هلام عيني في الموقع يستخدم كلاً من الآليات المستحثة بالأيونات والحساسة للحرارة لتحقيق الجيل. تم تحضير صيغ تحتوي على نسب مختلفة من البولوكسامير 407 وصمغ الجيلان (F1-F24) ومقارنتها فيما يتعلق بدرجة حرارة التبلور، قدرة التبلور، زمن التبلور، ودراسة الإطلاق والتخلل. تم اختبار الصيغة المثلى فيما يتعلق بتساوي التوتر، ومضادات الميكروبات، والتهيج في الأرانب. تتراوح درجة الحموضة في التركيبات من 6.7 إلى 7.3. المستحضرات التي اجتازت اختبار درجة حرارة التبلور بنجاح هي F6 وF7 وF9 وF10. وتراوحت نسبة المحتوى الدوائي لكلا العقارين (F6، F7، F9، F10) من 98.64% إلى 99.95%. في الموقع، أظهرت المواد الهلامية (F6، F7، F9، وF10) سلوكًا ريولوجيًا متدفقًا كاذبًا أو ترقق القص، كما يتضح من انخفاض اللزوجة مع زيادة السرعة الزاوية. الصيغة المثالية (F7) التي تحتوي على 17% بولوكسامير و0.5% صمغ جيلان حصلت على 15 ثانية من وقت التبلور عند 34 درجة مئوية وبقيت على شكل هلام لمدة 270 دقيقة. لقد كان متساوي التوتر ولم تظهر خلايا الدم الحمراء أي تغيير في الحجم والشكل عند تطبيق الجل في الموقع. تم تمديد إطلاق كلا العقارين ولم يلاحظ أي تهيج في عين الأرنب عند اختباره على الحيوانات. من خلال تحسين فترة الإقامة قبل القرنية والتوافر البيولوجي للعين نتيجة للإدارة الأقل تواترا، يمكن اعتبار تركيبة الجل الجديدة في الموقع بديلا متفوقا لقطرات العين التقليدية من جاتيفلوكساسين وبيتاميثازون لالتهابات العين.

التنزيلات

بيانات التنزيل غير متوفرة بعد.

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