Preparation and Evaluation of Solid Dispersion-Based Bilastine Effervescent Granules

المؤلفون

  • Mariam Hamid Ali Kirkuk Health Directorate, Iraqi Ministry of Health, Kirkuk, Iraq https://orcid.org/0009-0002-2600-7916
  • Kawthar Khalid Ahmed Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Iraq

DOI:

https://doi.org/10.54133/ajms.v6i2.806

الكلمات المفتاحية:

Bilastine، Effervescent granules solid dispersion، Kneading technique، PVP K30، PLX188

الملخص

الخلاصة: البلاستين دواء من الجيل الثاني من مضادات الهستامين لعلاج الالتهاب التحسسي للملتحمة الانفية،يصنف البلاستين لقلة ذوبانيته في الماء كدواء من الصنف الثاني. اثبتت تقنية المتشتت الصلب فعاليتها في تحسين ذوبان وسرعة تحرر العديد من الادوية غير الذائبة.

الهدف: تحسين ذوبانية وتحرر البلاستين عن طريقه تحضيره بصيغة المتشتت الصلب لغرض تحويله الى حبيبات فوارة.

الطرق: تم استخدام طريقة العجن لتحضير المتشتت الصلب للبلاستين باستخدام البولوكزامر188 و فينيل بيرلوريدون ك 30 وبالنسب 1:5و1:10و1:15 من الدواء والحامل المائي. قيمت جميع الصيغ من ناحية النسبة الانتاجية ومحتوى الدواء وقابلية الذوبان المائية. ثم خضعت الصيغ ذات التحسن العالي للذوبانية لاختبار سرعة مدى تحرر الدواء. تم تحليل الصيغة المثالية للمتشتت الصلب حراريا بوساطة المسح التفاضلي الكالوري، حيود الاشعة السينية، و باستخدام التحليل الطيفي للاشعة تحت الحمراء تم دراسة التفاعل بين الدواء والناقل المائي. حضرت صيغة المتشتت الصلب المثالية كحبيبات فوارة باستخدام التحبيب الرطب وخضوعها للتقييم ايضا.

النتائج:اظهرت صيغة المتشتت الصلب للبلاستين المحضرة باستخدام البولي فينيل بيرلوريدون ك 30 بنسبة 1:15 من الدواء والحامل المائي اعلى تحسين للذوبانية المائية واسرع تحرر للدواء,حيث حررت اكثر من 88.43% من الدواء في اول 15 دقيقة في الوسط الفوسفاتي ذو الرقم الهيدروجيني 6.8. كما أظهرت الحبيبات الفوارة المحضرة من صيغة المتشتت الصلب المثالية خصائص تدفق ممتازة، ووقت تفكك قدره 87 ثانية، ودرجة حموضة مقبولة تبلغ 5.9 و9.7 ملجم من الدواء المذاب في أول 5 دقائق.

الاستنتاج: تم تحسين ذوبانية دواء البلاستين بواسطة تقنية التشتت الصلب بما ساعد في تحضيره كحبيبات فوارة

التنزيلات

بيانات التنزيل غير متوفرة بعد.

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التنزيلات

منشور

2024-06-02

كيفية الاقتباس

Ali , M. H., & Ahmed, K. K. (2024). Preparation and Evaluation of Solid Dispersion-Based Bilastine Effervescent Granules. Al-Rafidain Journal of Medical Sciences, 6(2), 116–123. https://doi.org/10.54133/ajms.v6i2.806

إصدار

القسم

Original article

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